The objective of the present study was to design and develop microemulsion based gel formulation of imidazole substitute for enhancing its solubility and permeability. Topical permeability of bifonazole is very low. For this purpose, initially, solubility and permeability of bifonazole was determined in various vehicles. Dissimilar formulations of bifonazole in microemulsion base using isopropyl myristate as oil phase, Acrysol K150 as surfactant and plurol oleique as co-surfactant after preliminary screening of excipients. Carbopol 971 as gelling agent. Isopropyl myristate was chosen as oil phase due to its good solublizing capacity. Microemulsion existence region was specified using the pseudo-ternary phase diagrams for preparing dissimilar formulations. The system was optimized by ternary phase diagram. The equipped formulations were characterized for drug content, % transmittance, visual assessment, particle size, zeta potential and compare in-vitro diffusion study of prepared microemulsion based gel with marketed formulation, Skin irritation study. The optimized batch contains mean particle size of 28.57nm and zeta potential (ζ) -8.25mV and viscosity study and spreadability also in-vitro permeation study. In-vitro diffusion study of optimized formulation MEB2 carried out which gives satisfactory release. Therefore by formulating into microemulsion based gel the solubility of bifonazole was found to be significantly improved.
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